Deficiency of apolipoproteins a-i and c-iii and severe coronary heart disease

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Abstract
A 55‐year‐old woman with severe coronary arteriosclerosis and skin xanthomas is described. The patient had a normal total cholesterol level of 168 mg/dl. Her level of high‐density lipoprotein cholesterol was markedly reduced (3 mg/dl). On apolipoprotein analysis, apolipoproteins A‐I and C‐III were not detectable, and the level of apolipoprotein A‐II was found to be at a low level (3.5 mg/dl). This case may possibly belong to a distinct new disease entity of deficiencies of apolipoprotein A‐I and C‐III in which coronary arteriosclerosis appears prematurely and severely.