The influence of drugs on the physical stability of fatty suppositories.

Publisher Website
Google Scholar
Abstract
To examine the influence of drugs on the physicochemical stability of semisynthetic fatty suppositories, model suppositories containing various kinds of drugs were prepared with Witepsol H-15 and storage experiments were performed. The stability of pharmaceutical properties was largely dependent on the solubility of drugs in the fatty vehicle (So). The rate of polymorphic transition of the vehicle measured by X-ray diffraction was accelerated by lipid-soluble drugs but was not much affected by lipid-insoluble drugs. The melting points measured by DTA [differential thermal analysis] generally decreased with increasing So, but they all increased by about 2-3.degree. C during storage. The softening time decreased with increasing So. The release properties measured at 37.degree. C were dependent on the solubility of the drugs in the dissolution fluid (Sw) initially but became dependent on So during storage. This phenomenon is discussed on the basis of the transportation mechanism of drugs in the lipid phase.

This publication has 2 references indexed in Scilit: