Abnormal intestinal permeability in children with autism
- 1 September 1996
- journal article
- Published by Wiley in Acta Paediatrica
- Vol. 85 (9) , 1076-1079
- https://doi.org/10.1111/j.1651-2227.1996.tb14220.x
Abstract
We determined the occurrence of gut mucosal damage using the intestinal permeability test in 21 autistic children who had no clinical and laboratory findings consistent with known intestinal disorders. An altered intestinal permeability was found in 9 of the 21 (43%) autistic patients, but in none of the 40 controls. Compared to the controls, these nine patients showed a similar mean mannitol recovery, but a significantly higher mean lactulose recovery (1.64%± 1.43 vs 0.38%±0.14; P < 0.001). We speculate that an altered intestinal permeability could represent a possible mechanism for the increased passage through the gut mucosa of peptides derived from foods with subsequent behavioural abnormalities.Keywords
This publication has 2 references indexed in Scilit:
- Childhood psychosis and urinary excretion of peptides and protein-associated peptide complexesJournal of Autism and Developmental Disorders, 1982