Bizarre Cutaneous Neurofibromas

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Abstract
Bizarre cutaneous neurofibroma is an uncommon benign [human] neoplasm. Microscopically, it is usually characterized by stellate and polyhedral cells embedded in a myxoid stroma, and less commonly by solid sheets of epithelioid cells. Cellular pleomorphism and mitotic figures are regular features and have resulted in erroneous diagnosis of malignancy. The mucinous material has the staining characteristics of a sulfated mucosubstance, probably chondroitin sulfate B. Terms previously applied to this lesion include nerve sheath myxoma, Pacinian neurofibroma, myxoid neurofibroma and neurotheceoma.

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