Fibrinolysis

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Abstract
NORMAL human blood contains an inactive proteinase termed plasminogen or profibrinolysin that in the presence of certain activating substances is converted to the active enzyme plasmin or fibrinolysin. This enzyme is capable of activating and hydrolyzing the internal peptide bonds of the protein fibrin, the prime component of the blood clot, as well as other proteins containing structural sites suitable for activation by plasmin.It has been suggested1 that this enzyme in blood may be part of a fundamental homeostatic process that maintains the functional integrity of the vascular bed and thus is directly involved in the etiology of arteriosclerosis. . . .
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