A technique for the absolute measurement of activity using a gamma camera and computer

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Abstract
In a number of situations in gamma camera studies it may be useful to ascertain the quantity of activity of isotope in an organ. Examples are in liver sulfur colloid imaging the liver/spleen ratio is widely used as an indication of [human] cirrhosis and the absolute activity in the kidney can be used to obtain the glomerular filtration rate in renal studies using DTPA [diethylenetriaminepentaacetic acid]. In such studies it is important to correct the regional counts obtained on the gamma camera for the varying absorption in body tissue. This paper describes a general method for the measurement of activity in an organ using anterior, posterior and lateral views. Its application to liver colloid imaging is described.