FLUOXETINE IN DEPRESSED-PATIENTS - A COMPARISON WITH IMIPRAMINE

  • 1 January 1984
    • journal article
    • research article
    • Vol. 45  (10) , 414-419
Abstract
The clinical efficacy and safety of fluoxetine and imipramine were compared in a double-blind, 5-wk parallel study in 40 depressed outpatients. Mean scores for most depression scales improved more in patients taking fluoxetine than in those receiving imipramine (P < 0.05). Nine of 16 (56%) fluoxetine patients who completed the study and 1 of 19 (5%) imipramine patients were not at all depressed at the end of the study (P < 0.001). Seven fluoxetine patients and 14 imipramine patients reported 1 or more adverse effects during treatment; no fluoxetine patient terminated the study early for drug-related reasons. Fluoxetine apparently provides effective antidepressant activity with fewer and less troublesome side effects than imipramine.

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