Factitious urticaria (dermographism): treatment by cimetidine and chlorpheniramine in a randomized double-blind study

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Abstract
The H1-antihistamine chlorpheniramine and the H2-antihistamine cimetidine, given alone and in combination, were compared with placebo in 20 patients with factitious urticaria (dermographism), in a double-blind, randomized cross-over trial. The combination was the only treatment which significantly reduced weal size, flare size and duration of weal, compared with placebo, but other treatments approached statistical significance. Continuation of the most effective of the 4 treatments in 19 of the patients for 3 mo. without breaking the randomization code provided evidence of the greater effectiveness of combined cimetidine and chlorpheniramine. No significant side effects were noted.