Demonstration of two unique metabolites of arachidonic acid from phorbol ester-stimulated bovine lymphocytes
- 1 January 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 4 (10) , 1247-1251
- https://doi.org/10.1093/carcin/4.10.1247
Abstract
Treatment of bovine lymphocytes with phorbol esters activates an oxygen-dependent system for the formation of a class of arachidonic acid metabolites which appears distinct from prostaglandins, prostacyclins, thromboxanes and leukotrienes. A full activation of the system is achieved within minutes by 10−7 M 12-O-tetradecanoylphorbol-13-acetate. This activation can be largely prevented by the lipoxygenase inhibitors, 5,8,11,14-eicosatetraynoic acid and nordihydroguaiaretic acid.Keywords
This publication has 5 references indexed in Scilit:
- ANTAGONISM OF CONCANAVALIN-A CAPPING IN PHORBOL ESTER-ACTIVATED LYMPHOCYTES BY CALMODULIN INHIBITORS AND CERTAIN AMINO-ACID ESTERS1982
- Rapid acceleration of deoxyglucose transport by phorbol esters in bovine lymphocytesCarcinogenesis: Integrative Cancer Research, 1982
- INHIBITION OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE-ACCELERATED PHOSPHOLIPID-METABOLISM BY 5,8,11,14-EICOSATETRAYNOIC ACID1980
- Inhibition of phorbol ester-accelerated amino acid transport in bovine lymphocytesBiochimica et Biophysica Acta (BBA) - General Subjects, 1979
- RAPID STIMULATION OF PHOSPHOLIPID-METABOLISM IN BOVINE LYMPHOCYTES BY TUMOR-PROMOTING PHORBOL ESTERS1978