The biosynthesis of streptomycin. Incorporation of 14C-labelled compounds into streptose and N-methyl-l-glucosamine
- 1 April 1964
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 91 (1) , 31-35
- https://doi.org/10.1042/bj0910031
Abstract
The biosynthesis of streptomycin by Strepto-myces griseus was studied by adding to the growth medium possible precursors containing C14 and degrading the streptomycin produced. The N-methyl group in the N-methyl-L-glucosamine residue of streptomycin arises from the S-methyl group in methionine and not from formate. The streptose residue arises from glucose, and the C-formyl group in this branched-chain sugar arises from C-3 or C-4 of glucose. The C-formyl group does not arise from either formate or the S-methyl group in methionine.This publication has 10 references indexed in Scilit:
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