TRANSIENT POLYARTHRITIS ASSOCIATED WITH FAMILIAL HYPER-BETA-LIPOPROTEINEMIA

  • 1 January 1978
    • journal article
    • research article
    • Vol. 47  (187) , 249-259
Abstract
Heterozygous patients [41] with familial hyperbetalipoproteinemia were studied. Of these patients, 22 were observed for 4 years''. Transient flitting inflammatory joint symptoms were noted in 13 patients of this group. In 6 patients clinical, biochemical, radiological and radioisotope studies were carried out during the acute episode. This syndrome is apparently due to acute inflammatory periarthritis and peritendinitis. Radioactive Xe clearance is not prolonged as occurring in inflammatory synovitis although there is elevation of the ratioactive Tc uptake over the affected joints suggesting that the blood flow to the affected area is increased. This is the largest group of patients with this complication reported to date and recognition of this may prove to be an important aspect of case finding in this disorder. The treatment of hyperlipidemia at an early stage may contribute to a reduction in the morbidity and mortality from vascular disease. No further elucidation of the pathogenesis of the arthropathy was made but a possible relationship between undue exercise and the onset of joint symptoms was observed.

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