Dose-Response Tests in Field Surveys

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Abstract
Single static biochemical measures that are commonly used in field surveys often do not capture the dynamic metabolic situation that is most closely related to nutritional status. In contrast, short-term dose-response tests provide more reliable information about nutritional status for some nutrients, but not for others. In vivo response tests for vitamin A and for iron are promising, and in vitro enzyme stimulation tests for thiamin, riboflavin, pyridoxine, and selenium have been widely used. In vivo response tests are constrained by the needs for a waiting period, often for two or more biological samples, and usually for sophisticated instrumentation. In large field surveys, dose-response tests may be best used on a subsample of the population studied.