Mechanism of the Grignard reaction
- 1 April 1989
- journal article
- review article
- Published by Wiley in Journal of Physical Organic Chemistry
- Vol. 2 (3) , 205-213
- https://doi.org/10.1002/poc.610020303
Abstract
Mechanism of the Grignard reactions of aromatic ketones in THF was studied by spectroscopic and kinetic methods. The stable radical intermediates generated in the initial electron transfer from Grignard reagent to ketones are in a state of aggregated dimer of corresponding ion–radical pairs; in which two ketone anion radicals are bridged by a dimer di–cation of Grignard reagent. Subsequent alkyl radical transfer from dimeric Grignard reagent cation moiety to ketone anion radical aggregated each other are promoted by a participation of another neutral Grignard reagent. Proposed mechanism by present authors is able to explain well addition products/reduction products ratios in the Grignard reactions.Keywords
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