Analysis of the role of withdrawal state in morphine−induced supersensitivity to acetylcholine in mouse ileum

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Abstract
An attempt has been made to study the possible role played by the withdrawal state in morphine−induced supersensitivity to acetylcholine in mouse isolated ileum. Chronic morphine treatment for 5 days produced a significant supersensitivity to acetylcholine in the ileum. This supersensitivity was not altered significantly by the addition of morphine to the bathing medium–−a measure to avoid the precipitation of the withdrawal state. This indicates that the supersensitivity obtained does not represent the state of withdrawal and is the result of chronic morphine treatment.