Topically Applied Steroids in Active Herpes Simplex Keratitis

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Abstract
Topical administration of medrysone 1.0% produced a detrimental effect on active infection of the corneal epithelium by herpes simplex virus. Treatment with this drug resulted in a keratitis that was more severe in its clinical characteristics and ran a more prolonged course than the disease observed in control animals. A ten-day course of therapy also resulted in a prolongation of the period during which virus could be cultured from the eye. The undesirable effects produced by medrysone 1.0% were not as pronounced as those which followed administration of dexamethasone phosphate 0.1%.

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