Overexpression of Osteopontin Is Associated with More Aggressive Phenotypes in Human Non–Small Cell Lung Cancer
Open Access
- 1 July 2005
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 11 (13) , 4646-4652
- https://doi.org/10.1158/1078-0432.ccr-04-2013
Abstract
Purpose: The extracellular matrix (ECM) molecule osteopontin is implicated in many pathologic processes, including inflammation, cell proliferation, ECM invasion, tumor progression, and metastasis. The present study evaluated the clinical and biological importance of osteopontin in human lung cancer.Keywords
This publication has 28 references indexed in Scilit:
- Osteopontin as an Adjunct to CA125 in Detecting Recurrent Ovarian CancerClinical Cancer Research, 2004
- Utility of osteopontin as a biomarker in recurrent epithelial ovarian cancerGynecologic Oncology, 2004
- Osteopontin enhances the cell proliferation induced by the epidermal growth factor in human prostate cancer cellsThe Prostate, 2003
- Osteopontin Stimulates Cell Motility and Nuclear Factor κB-mediated Secretion of Urokinase Type Plasminogen Activator through Phosphatidylinositol 3-Kinase/Akt Signaling Pathways in Breast Cancer CellsJournal of Biological Chemistry, 2003
- Osteopontin Induces Nuclear Factor κB-mediated Promatrix Metalloproteinase-2 Activation through IκBα/IKK Signaling Pathways, and Curcumin (Diferulolylmethane) Down-regulates These PathwaysJournal of Biological Chemistry, 2003
- Cancer Statistics, 2003CA: A Cancer Journal for Clinicians, 2003
- Plasma osteopontinCancer, 2002
- New functions for the matrix metalloproteinases in cancer progressionNature Reviews Cancer, 2002
- Osteopontin induces increased invasiveness and plasminogen activator expression of human mammary epithelial cellsOncogene, 1999
- Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)Science, 1996