Mutagenicity of Benzidine and Related Compounds Employed in the Detection of Hemoglobin

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Abstract
Seven compounds commonly used as chromagens for the detection of hemoglobin and its derivatives have been assayed for mutagenicity employing the Salmonella/mammalian niicrosome test. Three of these compounds, benzidine, o-dianisidine, and o-tolidine, were shown to be mutagenic. Since benzidine and o-tolidine are already known to be carcinogens, there is a high probability that o-dianisidine will also prove to be a carcinogen. Four compounds tested with this system, o-anisidine, diphenylamine, guaicol, and o-toluidine, were not mutagenic.

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