Hypercholesterolemia of Copper Deficiency Is Linked to Glutathione Metabolism and Regulation of Hepatic HMG-CoA Reductase
- 27 April 2009
- journal article
- review article
- Published by Oxford University Press (OUP) in Nutrition Reviews
- Vol. 51 (10) , 305-307
- https://doi.org/10.1111/j.1753-4887.1993.tb03061.x
Abstract
Copper deficiency in rats causes hypercholesterolemia and increases in hepatic glutathione concentration and HMG-CoA reductase activity. Prevention of the increase in hepatic glutathione abolished the other changes.Keywords
This publication has 12 references indexed in Scilit:
- Inhibition of elevated hepatic glutathione abolishes copper deficiency cholesterolemia 1The FASEB Journal, 1992
- The effect of copper deficiency on rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activityThe Journal of Nutritional Biochemistry, 1990
- Thiol/disulfide exchange between 3-hydroxy-3-methylglutaryl-CoA reductase and glutathione. A thermodynamically facile dithiol oxidation.Published by Elsevier ,1988
- Copper Deficiency and Tissue Glutathione Concentration in the RatExperimental Biology and Medicine, 1988
- Investigations on the mechanism of hypercholesterolemia observed in copper deficiency in ratsJournal of Biosciences, 1987
- ROLE OF REVERSIBLE OXIDATION-REDUCTION OF ENZYME THIOLS-DISULFIDES IN METABOLIC REGULATIONAnnual Review of Biochemistry, 1985
- Effects of Copper Deficiency on the Activity of the Selenoenzyme Glutathione Peroxidase and on Excretion and Tissue Retention of 75SeO32−Journal of Nutrition, 1982
- Copper deficiency and cholesterol metabolism in the ratAtherosclerosis, 1978
- Oxidation, Excretion, and Tissue Distribution of [26-14C] Cholesterol in Copper-Deficient RatsJournal of Nutrition, 1978
- Hypercholesterolemia in rats produced by an increase in the ratio of zinc to copper ingestedThe American Journal of Clinical Nutrition, 1973