Allopurinol: Alteration in Pyrimidine Metabolism in Man
- 24 July 1970
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 169 (3943) , 388-390
- https://doi.org/10.1126/science.169.3943.388
Abstract
In addition to its well-established inhibitory effect on uric acid synthesis, allopurinol appears to alter substantially pyrimidine metabolism, as evidenced by a striking increase in the urinary excretion of orotidine and orotic acid. Allopurinol ribonucleotide and xanthosine 5'-monophosphate are potent inhibitors of human erythrocyte orotidylic decarboxylase and provide a possible mechanism for this effect.Keywords
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