Study of Prostaglandins E1 and F2α on Isolated Mammalian Cardiac Tissue

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Abstract
Prostaglandins (PG) E1 and F2.alpha. over a dose range of 2.0 pg/ml to 15 .mu.g/ml were tested to determine if they affected the resting potential, action potential amplitude or action potential duration of isolated superfused canine cardiac Purkinje fibers or feline papillary muscles. The effect of PG on spontaneous rate in Purkinje fibers was also tested. PGE1 and PGF2.alpha. over a range of 1.0 pg/ml to 20 .mu.g/ml were tested to determine if these compounds had an inotropic effect on feline papillary muscle. In the range of concentrations tested, PGE1 and PGF2.alpha. do not significantly change the electrophysiologic or mechanical response tested.

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