Blood Compatible Carbon Nanotubes − Nano-based Neoproteoglycans
- 11 March 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Langmuir
- Vol. 22 (8) , 3461-3463
- https://doi.org/10.1021/la0534468
Abstract
Although nanotechnology has provided a rich variety of nanomaterials (1−100 nm) for in vivo medical applications, the blood compatibility of all these nanobiomaterials is still largely unexamined. Here, we report the preparation of blood-compatible carbon nanotubes (CNTs) that potentially represent the building blocks for nanodevices having in vivo applications. Activated partial thromboplastin time (APTT) and thromboelastography (TEG) studies prove that heparinization can significantly enhance the blood compatibility of nanomaterials.Keywords
This publication has 23 references indexed in Scilit:
- Polyethyleneimine Functionalized Single-Walled Carbon Nanotubes as a Substrate for Neuronal GrowthThe Journal of Physical Chemistry B, 2005
- Heparin-Binding Domains in Vascular BiologyArteriosclerosis, Thrombosis, and Vascular Biology, 2004
- Recommendations of the National Heart, Lung, and Blood Institute Nanotechnology Working GroupCirculation, 2003
- Enzyme-Coated Carbon Nanotubes as Single-Molecule BiosensorsNano Letters, 2003
- Protein unfolding — an important process in vivo?Current Opinion in Structural Biology, 2003
- The emerging field of nanotube biotechnologyNature Reviews Drug Discovery, 2003
- An in vitro examination of an extracellular matrix scaffold for use in wound healingInternational Journal of Experimental Pathology, 2002
- Nanomedicine: destination or journey?Nanotechnology, 2002
- Blood compatibility — a perspectiveJournal of Biomaterials Science, Polymer Edition, 2000
- Anti-clotting activity of endothelial cell cultures and heparan sulfate proteoglycansBiochemical and Biophysical Research Communications, 1982