Filaricidal effects of Cyclosporin-A against Dipetalonema viteae in Mastomys natalensis
- 1 January 1984
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 78 (5) , 670-671
- https://doi.org/10.1016/0035-9203(84)90236-0
Abstract
Outbred male Mastomys natalensis were injected subcutaneously with 100 infective larvae of Dipetalonema viteae obtained from Ornithodonts tartakovskyi. Groups of five animals were treated with 30 mg/kg of the immunosuppressive drug Cyclosporin-A daily for five days (experimental) or Miglyol 812 (control). One group served as untreated controls. Contrary to expectations, 60% of the animals were completely protected against D. viteae and the remainder were partially protected. The mechanism remains unknown.Keywords
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