ANTIGENIC RELATIONSHIPS OF HAEMOPHILUS PERTUSSIS, THE PARAPERTUSSIS BACILLUS, AND BRUCELLA BRONCHISEPTICA AS SHOWN BY CROSS PROTECTION TESTS IN MICE

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Abstract
Groups of mice injd. with H. pertussis and B. bronchiseptica vaccine, respectively, showed evidence of protection when challenged intracerebrally with living organisms of the homologous species. Cross-protection tests between H. pertussis and B. bronchiseptica gave evidence of a fair degree of protection, with results varying within a wide range from expt. to expt. When mice injd. with parapertussis vaccine were infected with H. pertussis, there was very little protection. Parapertussis-vaccinated mice challenged with B. bronchiseptica showed protection, which in some tests approached that obtained with B. bronchiseptica vaccine. The cross-protection tests are incomplete because of the lack of a parapertussis culture suitable for challenge. The poorest protection was with parapertussis-injected mice challenged with H. pertussis. suggesting that addition of parapertussis organisms to pertussis vaccine could not be expected to add to its effectiveness against H. pertussis infection.