Consequence of Cerulenin-Released Beta-Lactamase in Clinical Coliforms
- 1 January 1978
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 13 (1) , 121-123
- https://doi.org/10.1128/aac.13.1.121
Abstract
Periplasmic β-lactamase of certain clinical coliforms was released, without affecting cell viability, by perturbation of the outer membrane utilizing the fatty acid-mimicking antibiotic cerulenin. Release of such compartmentalized β-lactamase, at high population density, seems to provide an extra margin of resistance to the organisms against cephaloridine.Keywords
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