Plasma protein changes in primary hypertension in humans and rats.

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Abstract
To determine whether plasma protein changes may be associated with primary hypertension, we analyzed plasma proteins from essential hypertensive (EHT) patients and genetically hypertensive rats using two-dimensional electrophoresis. An additional plasma protein, having a molecular weight of 13,000 daltons and an isoelectric point of 4.5, was found in 82% of the patients with borderline or moderate hypertension (n = 29) and in all permanently hypertensive patients (n = 12). This protein was detected in 36% of normotensive (NT) subjects (n = 50). In the latter, the influence of family history, sex, and secondary hypertension were studied. Plasma proteins were also studied in spontaneously hypertensive rats (SHR). In all plasma from young male (n = 10) and female (n = 6) SHR, two additional proteins (molecular weight = 16,000 daltons, pHi = 4.7 and 5.1) were detectable. These plasma proteins were not detectable in male Wistar Kyoto rats (WKY) and in 50% of female WKY, and their frequency was 10% (n = 10) and 0% (n = 3) in normal male WKY and in male WKY rendered hypertensive by methylprednisolone, respectively. We conclude that these alterations of plasma proteins may be considered a biochemical feature of primary hypertension.