The Recovery of Immune Responsiveness after Treatment with Cyclophosphamide

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Abstract
The immune response in mice towards SRBC was suppressed with cyclophosphamide. The recovery from the suppressed state was examined in whole animals and in primary spleen cell cultures. A near-normal peak response in the number of haemolysin-forming cells was elicited when mice were challenged with antigen 4 days after an injection of cyclophosphamide. However, cell transfer and in vitro experiments demonstrated that spleens did not recover their normal competence even after 30 days. These two rates of recovery may be regarded as distinct phases in repopulation and the implications of these findings are discussed in terms of cell populations.

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