CIRCULATORY, RESPIRATORY AND ACID-BASE-BALANCE CHANGES PRODUCED BY ANESTHETICS IN RAT

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 35  (5) , 605-612
Abstract
The effects of several anesthetics [pentobarbital sodium, diethyl urethane, urethane-chloralose, urethane-.alpha.-chloralose, .alpha.-chloralose and morphine-chloralose] on some cardiovascular, respiratory and metabolic responses were studied in the rat. Drugs were given by the i.p. route and observations were made during a period of 3 h after the injection of the agent. Results were compared with normal values obtained from unanesthetized animals. Urethane produced a metabolic acidosis, chloralose increased heart rate and morphine-chloralose mixture produced a sustained hypoxia. None of these agents evoked arrhythmias in the rat. Effects of the anesthesia should be taken into account in the evaluation of drugs in anesthetized rats.

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