Ammonia Inhibits Protein Synthesis in Slices from Young Rat Brain
- 1 March 1984
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 42 (3) , 644-646
- https://doi.org/10.1111/j.1471-4159.1984.tb02730.x
Abstract
NH4Cl, widely used as an inhibitor of lysosomal protein degradation, strongly inhibits protein synthesis in neocortical slices from 10-day-old rats at a concentration of 10 mmol/l. Its usefulness in experiments with brain tissue is doubted. The possible meaning of the finding with respect to ammonia toxicity is briefly discussed.Keywords
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