Structure and Effects of Interferon-Gamma

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Abstract
This brief overview of the structure of interferon-γ (IFN-γ) and its biological activities emphasizes recent results with recombinant human and murine IFNs and compares this type IIIFN with the type I IFN-α and IFN-β. The amino acid sequence of human IFN-γ is presented. Its antiviral activity and cytostatic or cytotoxic effects are described. Its effects on the immune system, including enhancement of membrane antigen expression, macrophage activation, effects on B lymphocytes, enhancement of natural killer cell activity and the interaction between IFN-γ and interleukin 2 are discussed. The evidence for in vivo antitumour activity of IFN-γ is reviewed and the problem of the molecular mechanisms of IFN action is examined.

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