Effects of isoxicam and other non-steroidal anti-inflammatory drugs on arachidonic acid metabolism by rat peritoneal leucocytes

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Abstract
Inhibition of prostaglandin formation from [14C]arachidonic acid by rat peritoneal leucocytes occurred with nonsteroidal anti‐inflammatory drugs, their order of potency being indomethacin > piroxicam > naproxen > ibuprofen > isoxicam. At the lowest concentration tested (1 μg ml−1), indomethacin markedly increased the accumulation of lipoxygenase products in the cell incubates. Naproxen, ibuprofen or piroxicam 1 or 10 μg ml−1 resulted in smaller increases of lipoxygenase products, and there was only a small rise with these concentrations of isoxicam.