Tritium labelling of benzamide drugs
- 1 October 1983
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 20 (10) , 1153-1158
- https://doi.org/10.1002/jlcr.2580201004
Abstract
Methods for tritiation of sulpiride, sultopride and metoclopramide were developed and optimized. 3H‐sulpiride (7.1 Ci/mmol), 3H‐sultopride (2.1 Ci/mmol) and 3H‐metoclopramide (18.0 Ci/mmol) were obtained by hydrodebromination of the related bromo derivatives. The bromo derivatives were prepared, in turn, by appropriate procedures specified for each case.Keywords
This publication has 3 references indexed in Scilit:
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- Specific binding of [3H]sulpiride to rat striatal preparationsJournal of Pharmacy and Pharmacology, 1979
- High specific activity labelling of some tricyclic antidepressantsJournal of Labelled Compounds and Radiopharmaceuticals, 1978