Some Quantitative Temporal Characteristics of Carrageenin-Induced Pleurisy in the Rat

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Abstract
The intrapleural injection of 500 μg of carrageenin produces an acute inflammatory reaction in the rat in which it is possible to recover quantitatively the inflammatory cells that are mobilized and the exudate. The time courses of exudate formation and neutrophil mobilization strongly suggest that these phenomena are related. Both curves are sigmoid, and increase sharply between the first and third hours. Aspirin at 90 mg/kg, p.o., produced 83% inhibition of exudate formation at three hours but by the seventh hour the inhibition was only 31%. Neutrophil mobilization was only slightly inhibited by aspirin at three hours. However, the neutrophil mobilization which occurred between the third and seventh hours was completely blocked by aspirin. Monocyte mobilization started two hours after injection of the carrageenin and continued at a fixed rate through the seventh hour. There was no mobilization of monocytes in the aspirin-treated animals for the first five hours. Thereafter the rate of mobilization of these cells was similar in control and aspirin-treated animals.

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