Metabolism of 27-nor-24,25-dihydrolanosterol and 23,24,25,26,27-pentanor-dihydrolanosterol by rat liver hommogenate preparations.

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Abstract
The metabolism of 27-nor-24,25-dihydrolanosterol (1), which is an effective inhibitor of cholesterol biosynthesis from lanosterol, was studied using the unlabeled and 24,25-tritiated compounds. Compound 1 was transformed into the cholesterol analog, 27-norcholesterol, to the extent of 6.5% by incubation with rat liver homogenate under conditions such that lanosterol in the control experiment was converted to cholesterol to the extent of 24.8%. The structures of 2 other metabolites were determined. 23,24,25,26,27-Pentanordihydrolanosterol, which is also an inhibitor, was not transformed into the corresponding cholesterol analog, suggesting the importance of the side chain structure of lanosterol in cholesterol biosynthesis.

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