Effects of prostaglandin E2, I2 and F2.ALPHA. on systemic and renal hemodynamics, renal function and renin secretion in anesthetized dogs.

Publisher Website
Google Scholar
Abstract
Effects of intrarenal-arterial (i.r.a.) and i.v. infusions of PG[prostaglandin]E2, PGI2 and PGF2.alpha. on systemic blood pressure (BP), heart rate (HR), renal blood flow (RBF), urine volume (UV), renal function and plasma renin activity (PRA) of the renal venous blood (RVPRA) were investigated. A dose-dependent fall in BP was observed with PGE2 and PGI2 and was accompanied by a tachycardia (PGE2 < PGI2, i.r.a. < i.v.). PGE2 and PGI2 induced increases in RBF and UV in a roughly dose-dependent manner (PGE2 > PGI2, i.r.a. > i.v.), but antidiuresis was observed with the highest i.v. dose of PGI2 (300 ng/kg per min) due to a pronounced hypotension. Changes in electrolyte excretion induced by PGE2 and PGI2 were similar to the pattern of those in RBF or UV. PGE2 or PGI2 produced any significant changes in the glomerular filtration rate (GFR). The diuretic effect of PGE2 and PGF2.alpha. correlated with osmolar clearance (Cosm) (r [correlation coefficient] = 0.89, P < 0.01; r = 0.55, P < 0.01) and free water clearance (CH2O) (r = 0.52, P = < 0.01; r = 0.83, P < 0.01), but that of PGI2, only with Cosm (r = 0.74, P < 0.01). PGF2.alpha. produced the weakest changes in the parameters described above. PGE2 and PGI2 (30 ng/kg per min, i.r.a.), but not PGF2.alpha., produced a significant elevation of RVPRA without any significant change in BP. PGE2 plays a primary role in the kidney, but PGI2 is important in the regulation of the systemic circulation, and that PGE2 PGI2 and PGF2.alpha. all have different modes of action in producing diuresis. Both PGE2 and PGI2 may participate in the control of renin secretion.