Precautions in Medical Care of, and in Handling Materials from, Patients with Transmissible Virus Dementia (Creutzfeldt-Jakob Disease)

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Abstract
We have formulated a series of precautions to be observed in caring for patients with Creutzfeldt-Jakob disease and in handling their tissues. The virus resists inactivation by simple boiling in water. Also ineffective are 10 per cent formalin, 70 per cent alcohol and ionizing and ultraviolet radiation. Autoclaving for one hour at 121 °C and 20 psi inactivates the agent completely. Five per cent hypochlorite, 0.03 per cent permanganate, pnenolics and iodine solutions are adequate disinfectants inactivating large infective doses of the virus.