9.4-T NMR microimaging studies of hepatic metastases of human colorectal tumors in nude mice

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Abstract
We have applied NMR microimaging at 9.4 T to detect metastatic deposits in the liver of nude mice noninvasively, using an animal model for metastatic colon cancer that mimics several aspects of the human disease. Images were obtained with a resolution of 100 X 100 X 900 μm and the tumor deposits were clearly distinguished from the normal liver tissue with excellent contrast. Comparison of NMR images with corresponding histologic sections indicates that lesions as small as 900 μm were detected. © 1989 Academic Press, Inc.