Distribution and Metabolism of Menadiol Diphosphate in the Rat

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Abstract
Physiological doses of radioactive menadiol diphosphate, an active water-soluble form of vitamin K, were administered by intraperitoneal injection to vitamin K-deficient male rats. The compound was not concentrated by any tissue but was distributed throughout all body organs in a manner which was not influenced by the vitamin K status of the animal. Seventeen hours after an intraperitoneal injection of the radioactive vitamin about 50% of the activity had been excreted, mainly in the urine. There was a general association of the injected compound or its metabolites with the membranous fractions of the cell. The data also indicate that there was a rapid conversion of this water-soluble compound to more lipophilic forms of the vitamin.