Diminished Primary and Secondary Influenza Virus-Specific CD8+T-Cell Responses in CD4-Depleted Ig−/−Mice
Open Access
- 15 October 2000
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 74 (20) , 9762-9765
- https://doi.org/10.1128/jvi.74.20.9762-9765.2000
Abstract
Optimal expansion of influenza virus nucleoprotein (DbNP366)-specific CD8+ T cells following respiratory challenge of naive Ig−/− μMT mice was found to require CD4+ T-cell help, and this effect was also observed in primed animals. Absence of the CD4+population was consistently correlated with diminished recruitment of virus-specific CD8+ T cells to the infected lung, delayed virus clearance, and increased morbidity. The splenic CD8+set generated during the recall response in Ig−/− mice primed at least 6 months previously showed a normal profile of gamma interferon production subsequent to short-term, in vitro stimulation with viral peptide, irrespective of a concurrent CD4+T-cell response. Both the magnitude and the localization profiles of virus-specific CD8+ T cells, though perhaps not their functional characteristics, are thus modified in mice lacking CD4+ T cells.Keywords
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