Fidelity of deoxyribonucleic acid polymerases from normal and leukaemic human cells in polydeoxynucleotide replication
- 1 August 1974
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 141 (2) , 585-587
- https://doi.org/10.1042/bj1410585
Abstract
Although the relative incorporation of incorrect nucleotide (dCTP or dGTP) into poly(dA-dT)·poly(dA-dT) by partially purified 3–4S DNA polymerase from normal or leukaemic human cells was four to five times higher than that by the 6–7S DNA polymerase, no significant differences in the infidelity of these polymerases between normal and leukaemic cells were noted.Keywords
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