Potential effects of age-associated oxidative stress on mammalian oocytes/embryos
Open Access
- 1 January 1996
- journal article
- review article
- Published by Oxford University Press (OUP) in Molecular Human Reproduction
- Vol. 2 (10) , 717-724
- https://doi.org/10.1093/molehr/2.10.717
Abstract
This bioessay aims to explain the different effects of maternal ageing and postovulatory oocyte ageing on mammalian oocytes/embryos under the scope of ‘the oxygen radical-mitochondrial injury hypothesis of ageing’. This hypothesis assumes a key role in the senescent process of oxygen radical damage to mitochondrial DNA, proteins and lipids. It is proposed that a decrease in intracellular ATP concentrations and glutathione (GSH)/glutathione disulphide (GSSG) ratio together with a concomitant increase in cytosolic Ca2+ are major factors causing the observed detrimental effects of ageing on cytoskeletal fibres, fertilization and embryo development.Keywords
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