Host Determinants of Response to Antimicrobial Agents

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Abstract
Indigenous Microbial Flora Superinfection, a phenomenon characterized by the appearance of both microbiologic and clinical evidence of a new infection superimposed on the one being treated, is a common complication (about 2.5 per cent) of the use of all antibiotics. The factors that predispose to its development are very young and old age, pulmonary disease other than tuberculosis and the use of "broad-spectrum" or combined drugs.133 The organisms responsible for the new disease are, for the most part, members of the normal microbial flora that inhabits various areas of the body, especially the upper respiratory and intestinal tracts. In some . . .