Incidence and Risk Factors of Motor Neuron Disease in the Venice and Padua Districts of Italy, 1972–1979

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Abstract
105 patients with motor neuron disease (MND) from the Provinces of Padua and Venice were evaluated over an 8-year period (1972–1979). Average annual age-adjusted incidence rates rose from 0.49/100,000/year in 1972–1973 to 0.82/100,000/year in 1978–1979. Our epidemiologic survey showed a higher incidence in sparsely populated areas (1.7/100,000/year). A case-control study of 25 patients with MND revealed a statistically significant association with previous fractures (p < 0.01).

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