SKELETAL-MUSCLE INSULIN RESISTANCE DURING ESCHERICHIA-COLI BACTEREMIC SHOCK IN THE DOG

  • 1 January 1981
    • journal article
    • research article
    • Vol. 90  (5) , 853-859
Abstract
Skeletal muscle glucose uptake during close, intra-arterial insulin infusion was studied before and during live E. coli bacteremic shock in the dog. An in vivo, constant-flow perfused gracilis muscle preparation was used. Insulin infusion before shock resulted in a 395% increase in muscle glucose uptake, which was independent of changes in muscle lactate production or O2 uptake. At 1, 2 and 3 h of shock, insulin infusion had no effect on gracilis muscle glucose uptake. This loss of responsiveness to insulin occurred with no change in muscle O2 uptake, muscle venous PO2 [partial pressure of O2], or muscle blood flow (held constant). During nonshock control experiments, muscle glucose uptake in response to insulin infusion was maintained during the 3 h protocol. Thus, skeletal muscle insulin resistance develops early during bacteremic shock.

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