EXPERIMENTAL BOVINE PNEUMONIC PASTEURELLOSIS .1. PREVENTION OF THE DISEASE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 43  (3) , 262-271
Abstract
Fifteen 3-6 mo. old Hereford-cross calves were divided into 3 groups. The 1st group was inoculated with bovid herpesvirus 1 (Strain 108), the 2nd with a commercial intranasal vaccine against bovid herpesvirus 1 and the 3rd group acted as controls. At least 3 wk after vaccination, all calves were weaned, placed in an environmental chamber at 25.0.degree. C (days) and -13.3.degree. C (nights) and were challenged with an aerosol of bovid herpesvirus 1 followed 4 days later by an aerosol of Pasteurella haemolytica. All surviving calves were sacrificed 4 days after the 2nd aerosol. None of the calves inoculated with bovid herpesvirus 1 virus or the commercial vaccine developed a generalized pneumonia, although there were 1 or 2 nodules (4-8 mm diameter) in 2 calves given the commercial vaccine. Of the 5 control calves, 4 had extensive lobar pneumonia at necropsy and 2 died from the disease. Details of the clinical, pathological, bacteriological, virological and some of the serological findings are reported.