TYPE-IV AND TYPE-A-B COLLAGENS DO NOT ELICIT PLATELET-AGGREGATION OR THE SEROTONIN RELEASE REACTION
- 1 January 1979
- journal article
- research article
- Vol. 93 (3) , 499-505
Abstract
Human collagens were isolated from kidney, lung, skin, aorta, cartilage and placenta. Five different types were obtained, including 2 new molecular species, 1 characteristic of basement membranes, or type IV collagen, and the other the recently described A-B collagen derived from fetal membranes. All the collagens were purified and separated by combination of heat-gelation fractionation and salt fractionation. In neutral solution at 37.degree. C, neither type IV nor type A-B collagen elicited [human] platelet aggregation or 14C-serotonin release. Preincubation of platelets with both types IV and A-B collagen did not inhibit aggregation upon subsequent addition of collagen types I, II or III.This publication has 9 references indexed in Scilit:
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