Activity of orotate metabolizing enzyme complex and various urea-cycle enzymes in mutant mice with ornithine transcarbamylase deficiency
- 1 March 1982
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 38 (3) , 308-309
- https://doi.org/10.1007/bf01949358
Abstract
The overall activity of the enzyme complex consisting of orotate phosphoribosyl transferase and orotidine monophosphate decarboxylase, and of various enzymes of the urea cycle, has been studied in sparse-fur (spf) mutant mice with ornithine transcarbamylase deficiency. The enzyme complex has a lower overall activity, which could be caused by disturbed pyrimidine metabolism due to hyperammonemia. Other enzymes of the urea cycle do not show any significant change.This publication has 14 references indexed in Scilit:
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