Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication
- 1 October 1989
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 341 (6242) , 503-507
- https://doi.org/10.1038/341503a0
Abstract
Simian virus 40 large tumour antigen (T) is a replication origin binding protein required for viral DNA synthesis. Unphosphorylated T antigen is deficient in promoting DNA replication in vitro but can be activated by phosphorylation at residue threonine 124 by the cdc2 protein kinase. This observation demonstrates that T is regulated by phosphorylation and provides a model for cdc2 function in the control of DNA replication.Keywords
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