Magnetic resonance imaging (MR) (0.35 T [tesla]) and computed tomography (CT) were compared in 400 consecutive patients with suspected disease of the brain and cervical spinal cord. Of 325 positive diagnoses, MR detected abnormality while CT was normal in 93; MR was more specific in 68; MR and CT gave equivalent information in 129; CT was more specific in 32; and CT was positive while MR was normal in 3. MR was superior to CT in detection of multiple sclerosis, subcortical arteriosclerotic encephalopathy, posterior fossa infarcts and tumors, small extra-axial fluid collections and cervical syringomyelia. CT was preferable in evaluation of meningiomas and separation of tumor from edema. Using available sequence parameters, MR missed 3 1-cm calcified meningiomas which were clearly seen on CT. CT takes less time and may be preferable in patients with acute trauma, as well as very young or elderly individuals. Thus the 2 studies should be considered complementary.