Dissociation of HLA heavy chain and light chain (β2 microglobulin) expression on the cell surface of cutaneous malignancies

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Abstract
Biopsies from 29 malignant skin tumors and 4 benign dermatoses and 14 samples of normal skin were stained for cell surface membrane or cytoplasmic expression of HLA H chain and L chain (.beta.2 microglobulin) by use of the immunoperoxidase technique on frozen sections using monoclonal antibodies. A loss of .beta.2 microglobulin from the surface of malignant cells was shown in 24 out of 29 cutaneous malignancies and the presence of HLA H chain was shown in all 29 primary and secondary tumors. Expression of both heavy and light chains was observed in the 4 benign lesions and in normal epidermis in all samples examined. This would appear to be the first report of dissociation of H and L HLA chain expression in various forms of cutaneous malignancy.

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