Clonal Interference and the Evolution of RNA Viruses
- 10 September 1999
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 285 (5434) , 1745-1747
- https://doi.org/10.1126/science.285.5434.1745
Abstract
In asexual populations, beneficial mutations that occur in different lineages compete with one another. This phenomenon, known as clonal interference, ensures that those beneficial mutations that do achieve fixation are of large effect. Clonal interference also increases the time between fixations, thereby slowing the adaptation of asexual populations. The effects of clonal interference were measured in the asexual RNA virus vesicular stomatitis virus; rates and average effects of beneficial mutations were quantified.Keywords
This publication has 26 references indexed in Scilit:
- Diminishing Returns from Mutation Supply Rate in Asexual PopulationsScience, 1999
- Multiple molecular pathways for fitness recovery of an RNA virus debilitated by operation of Muller’s ratchet 1 1Edited by J. KarnJournal of Molecular Biology, 1999
- The Population Genetics of Adaptation: The Distribution of Factors Fixed during Adaptive EvolutionEvolution, 1998
- Evolutionary Dynamics of Fitness Recovery from the Debilitating Effects of Muller's RatchetEvolution, 1998
- Exponential increases of RNA virus fitness during large population transmissions.Proceedings of the National Academy of Sciences, 1995
- Rates of spontaneous mutation among RNA viruses.Proceedings of the National Academy of Sciences, 1993
- Long-Term Experimental Evolution in Escherichia coli. I. Adaptation and Divergence During 2,000 GenerationsThe American Naturalist, 1991
- Sequences of the major antibody binding epitopes of the Indiana serotype of vesicular stomatitis virusVirology, 1986
- Evolution in Sexual and Asexual PopulationsThe American Naturalist, 1965
- Some Genetic Aspects of SexThe American Naturalist, 1932